It happens with 10.1 and the new beta using the default skin. I am not sure how to post the log file The same video plays fine if I go to the library.
DVDPlayer: Opening: D:\Downloads\TV\Two and a Half Men\Season 9\Two.and.a.Half.Men.S09E19
22:50:49 T:2660 WARNING: CDVDMessageQueue(player):
ut MSGQ_NOT_INITIALIZED
22:50:49 T:4068 NOTICE: Creating InputStream
22:50:49 T:4068 ERROR: CDVDPlayer::OpenInputStream - error opening [D:\Downloads\TV\Two and a Half Men\Season 9\Two.and.a.Half.Men.S09E19
22:50:49 T:4068 NOTICE: CDVDPlayer::OnExit()
22:50:49 T:4068 NOTICE: CDVDPlayer::OnExit() deleting input stream
22:50:49 T:2660 ERROR: XBMC.PlayMedia could not play media: D:\Downloads\TV\Two and a Half Men\Season 9\Two.and.a.Half.Men.S09E19
22:50:49 T:2660 NOTICE: CDVDPlayer::CloseFile()
22:50:49 T:2660 WARNING: CDVDMessageQueue(player):
ut MSGQ_NOT_INITIALIZED
22:50:49 T:2660 NOTICE: DVDPlayer: waiting for threads to exit
22:50:49 T:2660 NOTICE: DVDPlayer: finished waiting
22:50:54 T:2660 NOTICE: DVDPlayer: Opening: D:\Downloads\TV\Two and a Half Men\Season 9\Two.and.a.Half.Men.S09E19.Palmdale
22:50:54 T:2660 WARNING: CDVDMessageQueue(player):
ut MSGQ_NOT_INITIALIZED
22:50:54 T:5024 NOTICE: Creating InputStream
22:50:54 T:5024 ERROR: CDVDPlayer::OpenInputStream - error opening [D:\Downloads\TV\Two and a Half Men\Season 9\Two.and.a.Half.Men.S09E19]
22:50:54 T:5024 NOTICE: CDVDPlayer::OnExit()
22:50:54 T:5024 NOTICE: CDVDPlayer::OnExit() deleting input stream
22:50:54 T:2660 ERROR: XBMC.PlayMedia could not play media: D:\Downloads\TV\Two and a Half Men\Season 9\Two.and.a.Half.Men.S09E19
22:50:54 T:2660 NOTICE: CDVDPlayer::CloseFile()
22:50:54 T:2660 WARNING: CDVDMessageQueue(player):
ut MSGQ_NOT_INITIALIZED
22:50:54 T:2660 NOTICE: DVDPlayer: waiting for threads to exit
22:50:54 T:2660 NOTICE: DVDPlayer: finished waiting