You could trust that the Handbrake developers actually know what they are doing and use their defaults (which amazingly work rather well).
HandbrakeCLI --preset "High Profile" -i /dev/dvd -o MovieName.mkv -f mkv
Of course, if you don't care about file size, MakeMKV is the better choice (makemkvcon --minlength 1200 mkv disc:0 all .). But since the OP does care about file size, the Handbrake suggestion above is a good compromise between size and quality.
PS Setting Handbrake's quality to 100% makes no sense. The quality is measured by the uncompressed result of rendering each frame. The normal compression ratio for Handbrake is 20% (-q 0.20) and is extremely close to the original DVD quality. Upping the ratio a bit (-q 0.17) produces only marginally better images and about 15-20% increase in file size.
Listen to this man. About the only good post I read in this thread.
To sum it up...if you want it left as is use makemkv. If you want to encode it use either the standard or high profile in handbrake. Don't change the CF factor. It will look great and the size will be greatly reduced.