Crumbs, I use all kinds of stuff like this. I'm a resource hog. It's largely unnecessary but I tend to be unnecessarily paranoid.
SpyBot every so often for the safety net (not TeaTimer - crap)
AdAware every so often for safety's sake - although I find it's pretty much useless
AVG as AV (incoming files only - and I quite like the web integration)
and MSE
I ignored an MSE warning (it flagged when I ran a W7 activator
) and I got a virus. Whoops. Serves me right for trying to outsmart M$.
It took Malware Bytes in safe mode to remove it. Nothing else worked. So MB is definitely my remover of choice.
I have been running AVG for a while, which tends to flag things before MSE does. Usually dodgy software that I've downloaded from dodgy places. No idea if MSE would have flagged it anyway if AVG wasn't installed - I suspect it would.
So basically I don't know the answer but if you're looking to keep things simple I would suggest that MSE is generally fine, but if you're not careful you'll be screwed anyway. MSE is installed as standard on W7 so the chances are that someone else will get the problem before you and it'll be fixed in an update.
And then Malware Bytes to fix it when it does go wrong occasionally